Article
The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.
Journal of translational medicine - 9 Dec 2020
Yuan Lin, Wang Leyuan, Du Xizi, Qin Ling, Yang Ming, Zhou Kai, Wu Mengping, Yang Yu, Zheng Zhiyuan, Xiang Yang, Qu Xiangping, Liu Huijun, Qin Xiaoqun, Liu Chi
Abstract excerpt
BACKGROUND: Late-onset asthma (LOA) is beginning to account for an increasing proportion of asthma patients, which is often underdiagnosed in the elderly. Studies on the possible relations between aging-related genes and LOA contribute to the diagnosis and treatment of LOA. Forkhead Box O3 (FOXO3) and TP53 are two classic aging-related genes. DNA methylation varies greatly with age which may play an important...
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