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Article

Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.

Pharmacogenetics - 1 Apr 2000

Yan L, Galinsky R E, Bernstein J A, Liggett S B, Weinshilboum R M

Abstract excerpt

Histamine is involved in the pathophysiology of asthma, and histamine N-methyltransferase (HNMT) plays the dominant role in histamine metabolism in human bronchial epithelium. Levels of HNMT activity in human tissues are controlled, in part, by inheritance. A common C314T polymorphism within the HNMT gene results in a Thr105Ile change in encoded amino acid, and the T314 allele is associated with decreased levels...

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Source

Identifiers

PMID: 10803682
DOI: 10.1097/00008571-200004000-00007

Genes

HNMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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