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Article

Rac1 modulation of the apical domain is negatively regulated by β (Heavy)-spectrin.

Mechanisms of development - 1 Jan 2000

Lee Seung-Kyu, Thomas Graham H

Abstract excerpt

Epithelial polarity and morphogenesis require the careful coordination of signaling and cytoskeletal elements. In this paper, we describe multiple genetic interactions between the apical cytoskeletal protein β(H) and Rac1 signaling in Drosophila: activation of Rac1 signaling by expression of the exchange factor Trio, is strongly enhanced by reducing β(H) levels, and such reductions in β(H) levels alone are shown...

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Identifiers

PMID: 21111816
DOI: 10.1016/j.mod.2010.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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