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Article

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.

Science (New York, N.Y.) - 20 Aug 2004

Begum Nasim A, Kinoshita Kazuo, Kakazu Naoki, Muramatsu Masamichi, Nagaoka Hitoshi, Shinkura Reiko, Biniszkiewicz Detlev, Boyer Laurie A, Jaenisch Rudolf, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID) is required for the DNA cleavage step in immunoglobulin class switch recombination (CSR). AID is proposed to deaminate cytosine to generate uracil (U) in either mRNA or DNA. In the second instance, DNA cleavage depends on uracil DNA glycosylase (UNG) for removal of U. Using phosphorylated histone gamma-H2AX focus formation as a marker of DNA cleavage, we found that the...

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Share to Cytidine Deaminase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AICDA (Activation-Induced Cytidine Deaminase)

Share to Genes, Immunoglobulin

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Source

Identifiers

PMID: 15326357
DOI: 10.1126/science.1098444

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.PMID 15326357Read ↗

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.Semantic proximity Read ↗

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.Semantic proximity Read ↗

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Semantic proximity Read ↗

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Semantic proximity Read ↗

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.Semantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.Semantic proximity Read ↗

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

Isolation of region-specific factors assembled on the Immunoglobulin heavy chain locus during antibody class switch recombinationSemantic proximity Read ↗

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.Semantic proximity Read ↗

Genomic Uracil Homeostasis during Normal B Cell Maturation and Loss of This Balance during B Cell Cancer DevelopmentSemantic proximity Read ↗

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