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Article

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.

The Journal of biological chemistry - 5 Jan 2007

Begum Nasim A, Izumi Nakako, Nishikori Momoko, Nagaoka Hitoshi, Shinkura Reiko, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID) and uracil DNA glycosylase (UNG) are required for class switch recombination (CSR). AID is involved in the DNA cleavage step of CSR, but the precise role of UNG is not yet understood. Mutations and deletions are footprints of abortive DNA cleavage in the immunoglobulin switch region in splenic B cells stimulated to undergo CSR. However, a UNG deficiency did not reduce...

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Source

Identifiers

PMID: 17090531
DOI: 10.1074/jbc.M607439200

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.PMID 17090531Read ↗

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.Semantic proximity Read ↗

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.Semantic proximity Read ↗

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationSemantic proximity Read ↗

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Semantic proximity Read ↗

Immunoglobulin class-switch recombination deficienciesSemantic proximity Read ↗

Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.Semantic proximity Read ↗

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.Semantic proximity Read ↗

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Semantic proximity Read ↗

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.Semantic proximity Read ↗

DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic HypermutationSemantic proximity Read ↗

Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch RepairSemantic proximity Read ↗

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