Article
Mice with a targeted disruption of the Fanconi anemia homolog Fanca.
Human molecular genetics - 22 Jul 2000
Cheng N C, van de Vrugt H J, van der Valk M A, Oostra A B, Krimpenfort P, de Vries Y, Joenje H, Berns A, Arwert F
Abstract excerpt
Fanconi anemia (FA) is a hereditary chromosomal instability syndrome with cancer predisposition. Bone marrow failure resulting in pancytopenia is the main cause of death of FA patients. Diagnosis of FA is based on their cellular hypersensitivity to DNA crosslinking agents and chromosome breakages. Somatic complementation experiments suggest the involvement of at least eight genes in FA. The gene for...
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