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Article

Induction of Fanconi anemia cellular phenotype in human 293 cells by overexpression of a mutant FAC allele.

The Journal of clinical investigation - 15 Feb 1996

Youssoufian H, Li Y, Martin M E, Buchwald M

Abstract excerpt

The polypeptide encoded by the Fanconi anemia (FA) complementation group C gene, FAC, binds to a group of cytoplasmic proteins in vitro and may form a multimeric complex. A known mutant allele of FAC resulting from the substitution of Pro for Leu at codon 554 fails to correct the sensitivity of FA group C cells to mitomycin C. We reasoned that overexpression of the mutant protein in a wild-type cellular...

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Identifiers

PMID: 8613549
DOI: 10.1172/JCI118519
PMCID: PMC507141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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