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Article

Acetylation of WRN Protein Regulates Its Stability by Inhibiting Ubiquitination

23 Apr 2010

Abstract excerpt

BACKGROUND: WRN is a multi-functional protein involving DNA replication, recombination and repair. WRN acetylation has been demonstrated playing an important role in response to DNA damage. We previously found that WRN acetylation can regulate its enzymatic activities and nuclear distribution. METHODOLOGY/PRINCIPAL FINDING: Here, we investigated the factors involved in WRN acetylation and found that CBP and p300...

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PMID: 20428248
DOI: 10.1371/journal.pone.0010341

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