Article
Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.
Trials - 14 Jan 2011
Staessen Jan A, Thijs Lutgarde, Stolarz-Skrzypek Katarzyna, Bacchieri Antonella, Barton John, Espositi Ezio Degli, de Leeuw Peter W, Dłużniewski Mirosław, Glorioso Nicola, Januszewicz Andrzej, Manunta Paolo, Milyagin Viktor, Nikitin Yuri, Souček Miroslav, Lanzani Chiara, Citterio Lorena, Timio Mario, Tykarski Andrzej, Ferrari Patrizia, Valentini Giovanni, Kawecka-Jaszcz Kalina, Bianchi Giuseppe
Abstract excerpt
BACKGROUND: The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na+,K+-ATPase and mutated adducin. Rostafu...
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