Article
Estrogen receptor α and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy.
The Journal of clinical endocrinology and metabolism - 1 Feb 2011
Sissung Tristan M, Danesi Romano, Kirkland C Tyler, Baum Caitlin E, Ockers Sandra B, Stein Erica V, Venzon David, Price Douglas K, Figg William D
Abstract excerpt
CONTEXT: Reactive estrogen species cause genotoxicity and interfere with docetaxel-mediated tubulin polymerization resulting in shortened survival in men with castrate-resistant prostate cancer (CRPC). OBJECTIVE: We hypothesized that polymorphisms in estrogen synthesis and estrogen targets (i.e., CYP19 and ERα) would be linked to interindividual variation in CRPC risk, docetaxel response, and overall survival in...
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