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Article

HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer.

JAMA oncology - 1 Apr 2020

Hearn Jason W D, Sweeney Christopher J, Almassi Nima, Reichard Chad A, Reddy Chandana A, Li Hong, Hobbs Brian, Jarrard David F, Chen Yu-Hui, Dreicer Robert, Garcia Jorge A, Carducci Michael A, DiPaola Robert S, Sharifi Nima

Abstract excerpt

Importance: The adrenal-restrictive HSD3B1(1245A) allele limits extragonadal dihydrotestosterone synthesis, whereas the adrenal-permissive HSD3B1(1245C) allele augments extragonadal dihydrotestosterone synthesis. Retrospective studies have suggested an association between the adrenal-permissive allele, the frequency of which is highest in white men, and early development of castration-resistant prostate cancer...

Topics

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Androgen Antagonists
Disease-Free Survival
Disease Progression
Docetaxel
Multienzyme Complexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Prostatic Neoplasms, Castration-Resistant

Steroid Isomerases

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Identifiers

PMID: 32053149
DOI: 10.1001/jamaoncol.2019.6496
PMCID: PMC7042830

Genes

HSD3B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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