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Article

ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2008

Sissung Tristan M, Baum Caitlin E, Deeken John, Price Douglas K, Aragon-Ching Jeanny, Steinberg Seth M, Dahut William, Sparreboom Alex, Figg William D

Abstract excerpt

PURPOSE: Polymorphisms that are associated with ABCB1 expression and function may be linked to treatment efficacy and the development of neutropenia and neurotoxicity in patients with androgen-independent prostate cancer receiving docetaxel. EXPERIMENTAL DESIGN: Patients with androgen-independent prostate cancer treated with docetaxel alone (n = 23) or docetaxel and thalidomide (n = 50) were genotyped for the...

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Source

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Identifiers

PMID: 18628469
DOI: 10.1158/1078-0432.CCR-07-4230
PMCID: PMC2723795

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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