Article
Estrogen receptor beta polymorphism is associated with prostate cancer risk.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2006
Thellenberg-Karlsson Camilla, Lindström Sara, Malmer Beatrice, Wiklund Fredrik, Augustsson-Bälter Katarina, Adami Hans-Olov, Stattin Par, Nilsson Maria, Dahlman-Wright Karin, Gustafsson Jan-Ake, Grönberg Henrik
Abstract excerpt
PURPOSE: After cloning of the second estrogen receptor, estrogen receptor beta (ERbeta) in 1996, increasing evidence of its importance in prostate cancer development has been obtained. ERbeta is thought to exert an antiproliferative and proapoptotic effect. We examined whether sequence variants in the ERbeta gene are associated with prostate cancer risk. EXPERIMENTAL DESIGN: We conducted a large population-based...
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