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Article

Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.

Journal of molecular biology - 16 Jun 2000

Gillmor S A, Takeuchi T, Yang S Q, Craik C S, Fletterick R J

Abstract excerpt

Ecotin is a dimeric serine protease inhibitor from Escherichia coli which binds proteases to form a hetero-tetramer with three distinct interfaces: an ecotin-ecotin dimer interface, a larger primary ecotin-protease interface, and a smaller secondary ecotin-protease interface. The contributions of these interfaces to binding and inhibition are unequal. To investigate the contribution and adaptability of each...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10843853
DOI: 10.1006/jmbi.2000.3812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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