Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults.

doi:10.1097/jcp.0b013e3181fc2bef

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Article

Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults.

Journal of clinical psychopharmacology - 1 Dec 2010

Lenze Eric J, Goate Alison M, Nowotny Petra, Dixon David, Shi Peichang, Bies Robert R, Lotrich Francis K, Rollman Bruce L, Shear M Katherine, Thompson Paul A, Andreescu Carmen, Pollock Bruce G

Abstract excerpt

OBJECTIVE: Generalized anxiety disorder (GAD) is common in older adults and can be treated with selective serotonin reuptake inhibitors (SSRIs). Genetic variation in the serotonin transporter gene promoter region is posited to be associated with SSRI efficacy: 2 polymorphisms (5-HTTLPR S/L and rs25531 g/a) form a haplotype with the La combination having higher transcription activity than other haplotypes. We...

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Identifiers

PMID: 21105279
DOI: 10.1097/jcp.0b013e3181fc2bef
PMCID: PMC3059101

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