Article
Age-dependent association of polymorphisms in the promoter and 5'-untranslated region of the norepinephrine transporter gene with generalized anxiety disorder.
Journal of affective disorders - 1 Jun 2020
Chang Hsin-An, Fang Wen-Hui, Tzeng Nian-Sheng, Liu Yia-Ping, Shyu Jia-Fwu, Wan Fang-Jung, Huang San-Yuan, Chang Tieh-Ching, Chang Chuan-Chia
Abstract excerpt
BACKGROUND: Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages. Here, we examine whether genetic variants in the NET gene are associated, in an age-specific manner, with increased risk of generalized anxiety disorder (GAD), one of the most disabling anxiety...
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