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Article

The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric Cancer

15 Dec 2011

Abstract excerpt

CD44 is a transmembrane glycoprotein and surface receptor for hyaluronan that is involved in the response of cells to their microenvironment. CD44 splice variants play roles in carcinogenesis, differentiation, and lymph node metastasis and are predictive of the prognosis for various carcinomas, including gastric cancer. Current data suggest that gastric tissue stem cells and gastric cancer stem cells both express...

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PMID: 22195236
DOI: 10.5009/gnl.2011.5.4.397

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