Article
Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populations.
European journal of human genetics : EJHG - 1 Feb 2011
Chen Fang, Stram Daniel O, Le Marchand Loïc, Monroe Kristine R, Kolonel Laurence N, Henderson Brian E, Haiman Christopher A
Abstract excerpt
Genome-wide association studies (GWAS) have identified common variants associated with breast cancer risk among women of European and Asian ancestries. To assess the generalizability across ethnic/racial populations of a risk score derived from genotyping 12 highly replicated breast cancer GWAS hits, we performed a case-control study (2224 cases and 2827 controls) nested in the Multiethnic Cohort (MEC) study,...
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