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Article

Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatment

25 Apr 2011

Abstract excerpt

Cellular senescence plays an important role in tumor suppression. The mitotic kinase Nek6 has recently been shown to be overexpressed in various cancers and has been implicated in tumorigenesis. Previously, we reported that the down-regulation of Nek6 expression was required for p53-induced senescence. In this study, we examined the effect of Nek6 overexpression on the premature senescence of cancer cells induced...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 21539811
DOI: 10.1016/j.bbrc.2011.04.083

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