Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition

29 Aug 2018

Abstract excerpt

Ionizing radiation (IR) is a conventional cancer therapeutic, to which cancer cells develop radioresistance with exposure. The residual cancer cells after radiation treatment also have increased metastatic potential. The mechanisms by which cancer cells develop radioresistance and gain metastatic potential are still unknown. In this study acute IR exposure induced cancer cell senescence and apoptosis, but after...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Mechanisms of cancer metastasis
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30158672
DOI: 10.1038/s41388-018-0460-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transitionPMID 30158672Read ↗

Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor CellsSemantic proximity Read ↗

Nek6 suppresses the premature senescence of human cancer cells induced by camptothecin and doxorubicin treatmentSemantic proximity Read ↗

Nek6 overexpression antagonizes p53-induced senescence in human cancer cellsSemantic proximity Read ↗

CDC6: from DNA replication to cell cycle checkpoints and oncogenesisSemantic proximity Read ↗

Cell Signaling Pathways That Promote Radioresistance of Cancer CellsSemantic proximity Read ↗

Radiation-induced signaling pathways that promote cancer cell survival (Review)Semantic proximity Read ↗

TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradationSemantic proximity Read ↗

UBE2C mediated radiotherapy resistance of head and neck squamous cell carcinoma by regulating oxidative-stress-relative apoptosisSemantic proximity Read ↗

NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitorSemantic proximity Read ↗

The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death.Semantic proximity Read ↗

BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repairSemantic proximity Read ↗

Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing RadiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.