Article
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrel.
Circulation journal : official journal of the Japanese Circulation Society - 1 Jan 2011
Sawada Takahiro, Shinke Toshiro, Shite Junya, Honjo Tomoyuki, Haraguchi Yoko, Nishio Ryo, Shinohara Masakazu, Toh Ryuji, Ishida Tatsuro, Kawamori Hiroyuki, Kozuki Amane, Inoue Takumi, Hariki Hirotoshi, Hirata Ken-ichi
Abstract excerpt
BACKGROUND: The cytochrome P450 (CYP) 2C19*2 polymorphism is associated with reduced responsiveness to clopidogrel and poor clinical outcome after stent implantation. Despite the high frequency of this polymorphism in Japanese patients, its contribution to cardiac events and stent thrombi after drug-eluting stent (DES) implantation is not clear in this population. METHODS AND RESULTS: One hundred Japanese...
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