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Article

Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention.

European heart journal - 1 Apr 2009

Sibbing Dirk, Stegherr Julia, Latz Wolfgang, Koch Werner, Mehilli Julinda, Dörrler Katharina, Morath Tanja, Schömig Albert, Kastrati Adnan, von Beckerath Nicolas

Abstract excerpt

AIMS: Several studies have demonstrated that the mutant *2 allele of the CYP2C19 681G>A loss-of-function polymorphism is associated with diminished metabolization of clopidogrel into its active thiol metabolite and an attenuated platelet response to clopidogrel treatment. It is not known whether patients carrying the mutant CYP2C19*2 allele have a higher risk of stent thrombosis (ST) compared with homozygous...

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Source

Identifiers

PMID: 19193675
DOI: 10.1093/eurheartj/ehp041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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