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Article

CYP2C19*2 genetic polymorphism and incidence of in-stent restenosis in patients on clopidogrel: a matched case-control study.

Drug metabolism and personalized therapy - 1 Jan 2021

Osama Sara, Wirth Francesca, Zahra Graziella, Barbara Christopher, Xuereb Robert G, Camilleri Liberato, Azzopardi Lilian M

Abstract excerpt

OBJECTIVES: The cytochrome P450 2C19*2 (CYP2C19*2) genetic polymorphism is associated with reduced clopidogrel bioactivation, increasing the risk of atherothrombotic complications after percutaneous coronary intervention (PCI). In-stent restenosis (ISR) is a complication that limits the long-term prognosis of PCI. The aim was to investigate the association between presence of the CYP2C19*2 allele and ISR within...

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PMID: 34851561
DOI: 10.1515/dmpt-2021-0160

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