Impact of cytochrome P450 2C19 loss-of-function polymorphism on intra-stent thrombi and lesion outcome after everolimus-eluting stent implantation compared to that after first-generation drug-eluting stent implantation.

doi:10.1016/j.ijcard.2014.11.068

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Article

Impact of cytochrome P450 2C19 loss-of-function polymorphism on intra-stent thrombi and lesion outcome after everolimus-eluting stent implantation compared to that after first-generation drug-eluting stent implantation.

International journal of cardiology - 20 Jan 2015

Konishi Akihide, Shinke Toshiro, Otake Hiromasa, Nishio Ryo, Sawada Takahiro, Takaya Tomofumi, Nakagawa Masayuki, Osue Tsuyoshi, Taniguchi Yu, Iwasaki Masamichi, Kinutani Hiroto, Masaru Kuroda, Takahashi Hachidai, Terashita Daisuke, Shite Junya, Hirata Ken-ichi

Abstract excerpt

BACKGROUND: The contribution of clopidogrel response due to cytochrome P450 (CYP) 2C19 loss-of-function polymorphism after drug-eluting stent (DES) implantation is unclear. METHODS: A total of 196 patients who had undergone optical coherence tomography (OCT) at 8 months following first-generation DES (120 lesions) and current-generation everolimus-eluting stent (EES) implantation (127 lesions) were enrolled....

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PMID: 25465810
DOI: 10.1016/j.ijcard.2014.11.068

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