Article
A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.
Nature - 3 May 1990
Salter R D, Benjamin R J, Wesley P K, Buxton S E, Garrett T P, Clayberger C, Krensky A M, Norment A M, Littman D R, Parham P
Abstract excerpt
Adhesion measurements between CD8 and 48 point mutants of HLA-A2.1 show that the CD8 alpha-chain binds to the alpha 3 domain of HLA-A2.1. Three clusters of alpha 3 residues contribute to the binding, with an exposed, negatively charged loop (residues 223-229) playing a dominant role. CD8 binding correlates with cytotoxic T-cell recognition and sensitivity to inhibition by anti-CD8 antibodies. Impaired...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD8 Antigens
- Cell Line
- HLA-A2 Antigen
- Humans
- Lymphocyte Activation
- Molecular Structure
- Mutation
- Protein Conformation
- Receptors, Antigen, T-Cell