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Article

Saturation mutagenesis of the Drosophila tRNA(Arg) gene B-Box intragenic promoter element: requirements for transcription activation and stable complex formation.

Nucleic acids research - 25 Mar 1990

Gaëta B A, Sharp S J, Stewart T S

Abstract excerpt

Transcription of eukaryotic tRNA genes is dependent on the A- and B-Box internal control regions (ICRs) and the upstream transcription modulatory region. The B-Box ICR spans nucleotides 52 to 62 and directs the primary binding of transcription factor C as the first step in the formation of a transcription complex. The conservation of the sequence of the B-Box in all tRNA species reflects its importance in both...

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Identifiers

PMID: 2109308
DOI: 10.1093/nar/18.6.1541
PMCID: PMC330523

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