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Article

Selective pressure to increase charge in immunodominant epitopes of the H3 hemagglutinin influenza protein.

Journal of molecular evolution - 1 Jan 2011

Pan Keyao, Long Jinxue, Sun Haoxin, Tobin Gregory J, Nara Peter L, Deem Michael W

Abstract excerpt

The evolutionary speed and the consequent immune escape of H3N2 influenza A virus make it an interesting evolutionary system. Charged amino acid residues are often significant contributors to the free energy of binding for protein-protein interactions, including antibody-antigen binding and ligand-receptor binding. We used Markov chain theory and maximum likelihood estimation to model the evolution of the number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21086120
DOI: 10.1007/s00239-010-9405-4
PMCID: PMC3033527

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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