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Article

Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies.

PloS one - 10 Nov 2010

van der Sluis Sophie, Verhage Matthijs, Posthuma Danielle, Dolan Conor V

Abstract excerpt

BACKGROUND: The variance explained by genetic variants as identified in (genome-wide) genetic association studies is typically small compared to family-based heritability estimates. Explanations of this 'missing heritability' have been mainly genetic, such as genetic heterogeneity and complex (epi-)genetic mechanisms. METHODOLOGY: We used comprehensive simulation studies to show that three phenotypic measurement...

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Identifiers

PMID: 21085666
DOI: 10.1371/journal.pone.0013929
PMCID: PMC2978099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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