Article
Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies.
PloS one - 10 Nov 2010
van der Sluis Sophie, Verhage Matthijs, Posthuma Danielle, Dolan Conor V
Abstract excerpt
BACKGROUND: The variance explained by genetic variants as identified in (genome-wide) genetic association studies is typically small compared to family-based heritability estimates. Explanations of this 'missing heritability' have been mainly genetic, such as genetic heterogeneity and complex (epi-)genetic mechanisms. METHODOLOGY: We used comprehensive simulation studies to show that three phenotypic measurement...
Topics
- Animals
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Models, Genetic
- Phenotype