Article
Using item response theory to model multiple phenotypes and their joint heritability in family data.
Genetic epidemiology - 1 Feb 2014
Fragoso Tiago M, Giolo Suely R, Pereira Alexandre C, de Andrade Mariza, Soler Julia M P
Abstract excerpt
Many important complex diseases are composed of a series of phenotypes, which makes the disease diagnosis and its genetic dissection difficult. The standard procedures to determine heritability in such complex diseases are either applied for single phenotype analyses or to compare findings across phenotypes or multidimensional reduction procedures, such as principal components analysis using all phenotypes....
Topics
- Age Factors
- Algorithms
- Disease
- Humans
- Markov Chains
- Metabolic Syndrome
- Models, Genetic
- Monte Carlo Method
- Pedigree
- Phenotype
- Quantitative Trait, Heritable