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Article

Brain-phenotype models fail for individuals who defy sample stereotypes.

Nature - 1 Sept 2022

Greene Abigail S, Shen Xilin, Noble Stephanie, Horien Corey, Hahn C Alice, Arora Jagriti, Tokoglu Fuyuze, Spann Marisa N, Carrión Carmen I, Barron Daniel S, Sanacora Gerard, Srihari Vinod H, Woods Scott W, Scheinost Dustin, Constable R Todd

Abstract excerpt

Individual differences in brain functional organization track a range of traits, symptoms and behaviours1-12. So far, work modelling linear brain-phenotype relationships has assumed that a single such relationship generalizes across all individuals, but models do not work equally well in all participants13,14. A better understanding of in whom models fail and why is crucial to revealing robust, useful and...

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Identifiers

PMID: 36002572
DOI: 10.1038/s41586-022-05118-w
PMCID: PMC9433326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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