Article
Cell-cycle inhibition by Helicobacter pylori L-asparaginase.
PloS one - 9 Nov 2010
Scotti Claudia, Sommi Patrizia, Pasquetto Maria Valentina, Cappelletti Donata, Stivala Simona, Mignosi Paola, Savio Monica, Chiarelli Laurent Roberto, Valentini Giovanna, Bolanos-Garcia Victor M, Merrell Douglas Scott, Franchini Silvia, Verona Maria Luisa, Bolis Cristina, Solcia Enrico, Manca Rachele, Franciotta Diego, Casasco Andrea, Filipazzi Paola, Zardini Elisabetta, Vannini Vanio
Abstract excerpt
Helicobacter pylori (H. pylori) is a major human pathogen causing chronic gastritis, peptic ulcer, gastric cancer, and mucosa-associated lymphoid tissue lymphoma. One of the mechanisms whereby it induces damage depends on its interference with proliferation of host tissues. We here describe the discovery of a novel bacterial factor able to inhibit the cell-cycle of exposed cells, both of gastric and non-gastric...
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