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Article

UU/UA dinucleotide frequency reduction in coding regions results in increased mRNA stability and protein expression.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2012

Al-Saif Maher, Khabar Khalid S A

Abstract excerpt

UU and UA dinucleotides are rare in mammalian genes and may offer natural selection against endoribonuclease-mediated mRNA decay. This study hypothesized that reducing UU and UA (UW) dinucleotides in the mRNA-coding sequence, including the codons and the dicodon boundaries, may promote resistance...

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Identifiers

PMID: 22434136
DOI: 10.1038/mt.2012.29
PMCID: PMC3345983

Genes

ZFP36

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22434136-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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