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Article

Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy.

Journal of virology - 1 Jan 2011

Kearney Mary, Spindler Jon, Shao Wei, Maldarelli Frank, Palmer Sarah, Hu Shiu-Lok, Lifson Jeffrey D, KewalRamani Vineet N, Mellors John W, Coffin John M, Ambrose Zandrea

Abstract excerpt

The impact of antiretroviral therapy (ART) on the genetics of simian immunodeficiency virus (SIV) or human immunodeficiency virus (HIV) populations has been incompletely characterized. We analyzed SIV genetic variation before, during, and after ART in a macaque model. Six pigtail macaques were infected with an SIV/HIV chimeric virus, RT-SHIV(mne), in which SIV reverse transcriptase (RT) was replaced by HIV-1 RT....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21084490
DOI: 10.1128/JVI.01701-10
PMCID: PMC3019993

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