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Article

Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate.

Virology - 10 Oct 2006

Taber Rachel, Rajakumar Premeela A, Fuller Deborah Heydenburg, Trichel Anita M, Dowling Patricia, Meleason David, Amedee Angela, Murphey-Corb Michael

Abstract excerpt

Determining the impact of antiretroviral therapy on virus evolution could advance the development of improved therapeutics/vaccines against HIV. Toward this goal, we analyzed virus burden, quasispecies complexity, and T cell responses in SIV/DeltaB670-infected rhesus macaques+/-treatment for 7 months with PMPA (2-30 weeks postinfection). Treatment divided the animals into two groups: poor responders (a reduction...

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Identifiers

PMID: 16884757
DOI: 10.1016/j.virol.2006.06.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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