Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FoxL2 and Smad3 coordinately regulate follistatin gene transcription.

The Journal of biological chemistry - 20 Mar 2009

Blount Amy L, Schmidt Karsten, Justice Nicholas J, Vale Wylie W, Fischer Wolfgang H, Bilezikjian Louise M

Abstract excerpt

Follistatin is a transcriptional target and a modulator of activin action. Through an autocrine/paracrine loop, activin controls follistatin levels and thus regulates its own bioavailability. In gonadotropic alphaT3-1 cells, activin induces follistatin transcription primarily through the action of Smad3 at an intronic Smad-binding element (SBE1). Using a proteomics approach, we searched for endogenous alphaT3-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activins
Share to Blepharoptosis
Share to Forkhead Box Protein L2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Introns

Share to Pituitary Gland

Share to Response Elements

Share to Smad3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 19106105
DOI: 10.1074/jbc.M806676200
PMCID: PMC2658057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FoxL2 and Smad3 coordinately regulate follistatin gene transcription.PMID 19106105Read ↗

Evidence Supporting a Role for SMAD2/3 in Bovine Early Embryonic Development: Potential Implications for Embryotropic Actions of Follistatin1Semantic proximity Read ↗

Follistatin: a multifunctional regulatory protein.Semantic proximity Read ↗

Activin signaling as an emerging target for therapeutic interventionsSemantic proximity Read ↗

Follistatin‐like 1 in vertebrate developmentSemantic proximity Read ↗

Role of bone morphogenetic protein signaling in bovine early embryonic development and stage specific embryotropic actions of follistatin†Semantic proximity Read ↗

Overexpression of Mouse Follistatin Causes Reproductive Defects in Transgenic MiceSemantic proximity Read ↗

Structural basis for the inhibition of activin signalling by follistatin.Semantic proximity Read ↗

Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members.Semantic proximity Read ↗

FOXL2 and BMP2 Act Cooperatively to Regulate Follistatin Gene Expression during Ovarian DevelopmentSemantic proximity Read ↗

Follistatin preferentially antagonizes activin rather than BMP signaling in Drosophila.Semantic proximity Read ↗

The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.Semantic proximity Read ↗

Evidence Supporting a Functional Requirement of SMAD4 for Bovine Preimplantation Embryonic Development: A Potential Link to Embryotrophic Actions of Follistatin1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.