Article
Sickle cell disease: no longer a single gene disorder.
Current opinion in pediatrics - 1 Feb 2001
Chui D H, Dover G J
Abstract excerpt
Patients who are homozygous for the sickle hemoglobin mutation can present with remarkably different clinical courses, varying from death in childhood, to recurrent painful vasoocclusive crises and multiple organ damage in adults, to being relatively well even until old age. Increasing numbers of...
Topics
- Adult
- Anemia, Sickle Cell
- Child
- Databases, Factual
- Gene Expression Regulation
- Globins
- Humans
- Mutation
- Phenotype
- Polymorphism, Genetic