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Article

Discriminative accuracy of genomic profiling comparing multiplicative and additive risk models.

European journal of human genetics : EJHG - 1 Feb 2011

Moonesinghe Ramal, Khoury Muin J, Liu Tiebin, Janssens A Cecile J W

Abstract excerpt

Genetic prediction of common diseases is based on testing multiple genetic variants with weak effect sizes. Standard logistic regression and Cox Proportional Hazard models that assess the combined effect of multiple variants on disease risk assume multiplicative joint effects of the variants, but this assumption may not be correct. The risk model chosen may affect the predictive accuracy of genomic profiling. We...

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Identifiers

PMID: 21081969
DOI: 10.1038/ejhg.2010.165
PMCID: PMC3025793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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