Analytical and simulation methods for estimating the potential predictive ability of genetic profiling: a comparison of methods and results.

Abstract excerpt

Various modeling methods have been proposed to estimate the potential predictive ability of polygenic risk variants that predispose to various common diseases. However, it is unknown whether differences between them affect their conclusions on predictive ability. We reviewed input parameters, assumptions and output of the five most common methods and compared their estimates of the area under the receiver...

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