Article
Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.
The Journal of clinical endocrinology and metabolism - 1 Mar 2007
Tanabe Atsushi, Yanagiya Takahiro, Iida Aritoshi, Saito Susumu, Sekine Akihiro, Takahashi Atsushi, Nakamura Takahiro, Tsunoda Tatsuhiko, Kamohara Seika, Nakata Yoshio, Kotani Kazuaki, Komatsu Ryoya, Itoh Naoto, Mineo Ikuo, Wada Jun, Funahashi Tohru, Miyazaki Shigeru, Tokunaga Katsuto, Hamaguchi Kazuyuki, Shimada Tatsuo, Tanaka Kiyoji, Yamada Kentaro, Hanafusa Toshiaki, Oikawa Shinichi, Yoshimatsu Hironobu, Sakata Toshiie, Matsuzawa Yuji, Kamatani Naoyuki, Nakamura Yusuke, Hotta Kikuko
Abstract excerpt
CONTEXT: Genetic factors are important for the development of obesity. However, the genetic background of obesity still remains unclear. OBJECTIVE: Our objective was to search for obesity-related genes using a large number of gene-based single-nucleotide polymorphisms (SNPs). DESIGN AND SETTING: We conducted case-control association analyses using 94 obese patients and 658 controls with 62,663 SNPs selected from...
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