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Article

Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity.

Journal of obesity - 1 Jan 2024

Santana Cinthia Vila Nova, Magno Luiz Alexandre Viana, Ramos Adauto Versiani, Rios Maria Angélica, Sandrim Valéria Cristina, De Marco Luiz Armando, de Miranda Débora Marques, Romano-Silva Marco Aurélio

Abstract excerpt

Objective: Genetic variability significantly impacts metabolism, weight gain, and feeding behaviors, predisposing individuals to obesity. This study explored how variations in key genes related to obesity-FOXO3A (forkhead box O3), AMPK (protein kinase AMP-activated), and POMC (proopiomelanocortin)-are associated with extreme obesity (EOB). Methods: We conducted a case-control study with 251 EOB patients and 212...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39484290
DOI: 10.1155/2024/3813621
PMCID: PMC11527528

Genes

POMC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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