Article
The cytochrome 2C19*2 and *3 alleles attenuate response to clopidogrel similarly in East Asian patients undergoing elective percutaneous coronary intervention.
Thrombosis research - 1 Jan 2011
Hwang Seok-Jae, Jeong Young-Hoon, Kim In-Suk, Koh Jin-Sin, Kang Min-Kyung, Park Yongwhi, Kwak Choong Hwan, Hwang Jin-Yong
Abstract excerpt
INTRODUCTION: Carriage of CYP2C19*2 allele is associated with diminished platelet response to clopidogrel. However, the loss-of-function impact of CYP2C19*3 allele on antiplatelet effect of clopidogrel has not been definitely verified. We conducted this study to compare decreased response to clopidogrel according to carriage of CYP2C19*2 vs. *3 allele. MATERIALS AND METHODS: The study included 190 consecutive...
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