Article
Impact of CYP2C19 Polymorphisms on Clinical Outcomes and Antiplatelet Potency of Clopidogrel in Caucasian Poststroke Survivors.
American journal of therapeutics - 1 Jan 2000
Tomek Aleš, Matʼoška Václav, Frýdmanová Alena, Magerová Hana, Šrámek Martin, Paulasova-Schwabová Jaroslava, Růžičková Tereza, Janský Petr, Šarbochová Ivana, Hadačová Ivana, Kaplan Vojtěch, Lacinová Zuzana, Táborský Luděk, Serebruany Victor
Abstract excerpt
BACKGROUND: Variable response after clopidogrel is well documented and may affect major adverse clinical events after stroke. Impact of CYP2C19 genetic polymorphisms is an established marker linked to variable response after clopidogrel. However, the association of certain genetic polymorphisms with prediction of major adverse clinical events following stroke still remains controversial, especially in Caucasians....
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