Article
Effect of CYP2C19*2 and *3 loss-of-function alleles on platelet reactivity and adverse clinical events in East Asian acute myocardial infarction survivors treated with clopidogrel and aspirin.
Circulation. Cardiovascular interventions - 1 Dec 2011
Jeong Young-Hoon, Tantry Udaya S, Kim In-Suk, Koh Jin-Sin, Kwon Tae Jung, Park Yongwhi, Hwang Seok-Jae, Bliden Kevin P, Kwak Choong Hwan, Hwang Jin-Yong, Gurbel Paul A
Abstract excerpt
BACKGROUND: As compared with whites, East Asians more often carry the cytochrome P450 (CYP) 2C19 loss-of-function (LOF) allele with the CYP2C19*3 variant. The influence of the CYP2C19 LOF alleles (*2 and *3) on clopidogrel response and clinical outcomes in East Asians with acute myocardial infarction (AMI) has not been reported. We sought to evaluate the effect of the CYP2C19 variants on clopidogrel...
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