Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of MSK1 in the malignant phenotype of Ras-transformed mouse fibroblasts.

The Journal of biological chemistry - 7 Jan 2011

Pérez-Cadahía Beatriz, Drobic Bojan, Espino Paula S, He Shihua, Mandal Soma, Healy Shannon, Davie James R

Abstract excerpt

Activated by the RAS-MAPK signaling pathway, MSK1 is recruited to immediate-early gene (IEG) regulatory regions, where it phosphorylates histone H3 at Ser-10 or Ser-28. Chromatin remodelers and modifiers are then recruited by 14-3-3 proteins, readers of phosphoserine marks, leading to the occupancy of IEG promoters by the initiation-engaged form of RNA polymerase II and the onset of transcription. In this study,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Genes, Immediate-Early

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoquinolines

Share to Oncogene Protein p21(ras)

Share to Phorbol Esters

Share to Proto-Oncogene Proteins c-fos

Share to Proto-Oncogene Proteins c-jun

Share to Ribosomal Protein S6 Kinases, 90-kDa

Source

Open in PubMed Open full text

Identifiers

PMID: 21071437
DOI: 10.1074/jbc.M110.156687
PMCID: PMC3013000

Genes

JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of MSK1 in the malignant phenotype of Ras-transformed mouse fibroblasts.PMID 21071437Read ↗

Histone H3 phosphorylation, immediate-early gene expression, and the nucleosomal response: a historical perspective<sup>1</sup>This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.Semantic proximity Read ↗

Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1.Semantic proximity Read ↗

Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways.Semantic proximity Read ↗

Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.Semantic proximity Read ↗

Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor.Semantic proximity Read ↗

MK3 modulation affects BMI1-dependent and independent cell cycle check-points.Semantic proximity Read ↗

Mitogen-induced distinct epialleles are phosphorylated at either H3S10 or H3S28, depending on H3K27 acetylation.Semantic proximity Read ↗

Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism.Semantic proximity Read ↗

Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.Semantic proximity Read ↗

High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model.Semantic proximity Read ↗

Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.Semantic proximity Read ↗

TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family OncoproteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.