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Article

TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins

1 Jul 2002

Abstract excerpt

We demonstrate that transformation-transactivation domain-associated protein (TRRAP) binding and the recruitment of histone H3 and H4 acetyltransferase activities are required for the transactivation of a silent telomerase reverse transcriptase (TERT) gene in exponentially growing human fibroblasts by c-Myc or N-Myc protein. However, recruitment of TRRAP by c- or N-Myc is dispensable for the partial induction of...

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Identifiers

PMID: 12077335
DOI: 10.1128/mcb.22.14.5054-5063.2002

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