GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

doi:10.1016/s0896-6273(00)80541-3

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Article

GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

Neuron - 1 Aug 1998

Enomoto H, Araki T, Jackman A, Heuckeroth R O, Snider W D, Johnson E M, Milbrandt J

Abstract excerpt

Glial cell line-derived neurotrophic factor (GDNF) signals through a receptor complex composed of the Ret tyrosine kinase and a glycosylphosphatidylinositol- (GPI-) anchored cell surface coreceptor, either GDNF family receptor alpha1 (GFR alpha1) or GFR alpha2. To investigate the usage of these c...

Topics

Animals
Cell Survival
Central Nervous System
Drosophila Proteins
Enteric Nervous System
Female
Gene Targeting
Glial Cell Line-Derived Neurotrophic Factor Receptors
Kidney
Mice
Mutation
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peripheral Nervous System

Pregnancy

Pregnancy Outcome

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-ret

Receptor Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 9728913
DOI: 10.1016/s0896-6273(00)80541-3

Genes

GDNF
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9728913-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.PMID 9728913Read ↗

Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.Semantic proximity Read ↗

Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles.Semantic proximity Read ↗

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Joint disruption of <i>Ret</i> and <i>Ednrb</i> transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung diseaseSemantic proximity Read ↗

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