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Article

Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.

Journal of neurochemistry - 1 Aug 2007

Gustin Jason A, Yang Mao, Johnson Eugene M, Milbrandt Jeffrey

Abstract excerpt

Glial cell derived neurotrophic factor (GDNF)-dependent receptor tyrosine kinase RET activity is required for proper development of the nervous system and genitourinary tract. Loss-of-function mutations in RET are associated with enteric nervous system abnormalities (Hirschsprung disease) and renal deficits (Potter's syndrome), whereas activating mutations lead to hereditary cancer syndromes (multiple endocrine...

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Source

Identifiers

PMID: 17663753
DOI: 10.1111/j.1471-4159.2007.04624.x

Genes

RET
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.PMID 17663753Read ↗

A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia.Semantic proximity Read ↗

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Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.Semantic proximity Read ↗

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic PotentialSemantic proximity Read ↗

Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth.Semantic proximity Read ↗

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteinsSemantic proximity Read ↗

The Drosophila Ret gene functions in the stomatogastric nervous system with the Maverick TGFβ ligand and the Gfrl co-receptor.Semantic proximity Read ↗

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Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.Semantic proximity Read ↗

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potencySemantic proximity Read ↗

Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in miceSemantic proximity Read ↗

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