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Article

Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1

9 Nov 2010

Abstract excerpt

Stem cells are permanent residents of tissues and thought to be targets of cancer initiation. The frequent, and often early, upregulation of the FOXM1 transcription factor in the majority of human cancers suggests that it may participate in the initiation of human tumorigenesis. However, this hypothesis has not been tested. Herein, we show that targeting the ectopic expression of FOXM1 to the highly clonogenic...

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PMID: 21062979
DOI: 10.1158/0008-5472.can-10-2173

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