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Monoallelic MUTYH pathogenic variants ascertained via multi-gene hereditary cancer panels are not associated with colorectal, endometrial, or breast cancer.

Familial cancer - 1 Oct 2022

Thompson Amanda Bartenbaker, Sutcliffe Erin G, Arvai Kevin, Roberts Maegan E, Susswein Lisa R, Marshall Megan L, Torene Rebecca, Postula Kristen J Vogel, Hruska Kathleen S, Bai Shaochun

Abstract excerpt

We aimed to determine whether monoallelic MUTYH pathogenic and likely pathogenic variants (PVs) are associated with colorectal, breast, and endometrial cancer. Cases were individuals with colorectal, female breast, or endometrial cancer who reported European ancestry alone and underwent a multi-gene hereditary cancer panel at a large reference laboratory. Controls were individuals of European (non-Finnish)...

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PMID: 34981295
DOI: 10.1007/s10689-021-00285-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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