Article
Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
Archives of internal medicine - 8 Nov 2010
Shen Haiqing, Damcott Coleen M, Rampersaud Evadnie, Pollin Toni I, Horenstein Richard B, McArdle Patrick F, Peyser Patricia A, Bielak Lawrence F, Post Wendy S, Chang Yen-Pei C, Ryan Kathleen A, Miller Michael, Rumberger John A, Sheedy Patrick F, Shelton John, O'Connell Jeffrey R, Shuldiner Alan R, Mitchell Braxton D
Abstract excerpt
BACKGROUND: Elevated low-density lipoprotein cholesterol (LDL-C) levels are a major cardiovascular disease risk factor. Genetic factors are an important determinant of LDL-C levels. METHODS: To identify single nucleotide polymorphisms associated with LDL-C and subclinical coronary atherosclerosis, we performed a genome-wide association study of LDL-C in 841 asymptomatic Amish individuals aged 20 to 80 years, with...
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